English | 408 pages | Wiley-Blackwell; 2nd edition (March 9, 2009) | 1405175192 | PDF | 4.55 Mb

Asymmetric synthesis has become a major aspect of modern organic chemistry. The stereochemical properties of an organic compound are often essential to its bioactivity, and the need for stereochemically pure pharmaceutical products is a key example of the importance of stereochemical control in organic synthesis. However, achieving high levels of stereoselectivity in the synthesis of complex natural products represents a considerable intellectual and practical challenge for chemists.
Written from a synthetic organic chemistry perspective, this text provides a practical overview of the field, illustrating a wide range of transformations that can be achieved. The book captures the latest advances in asymmetric catalysis with emphasis placed on non-enzymatic methods.
Topics covered include
Reduction of alkenes, ketones and imines
Nucleophilic addition to carbonyl compounds
Catalytic carbon-carbon bond forming reactions
Catalytic reactions involving metal carbenoids
Conjugate addition reactions
Catalysis in Asymmetric Synthesis bridges the gap between undergraduate and advanced level textbooks and provides a convenient point of entry to the primary literature for the experienced synthetic organic chemist.