This book brings together the impact of Prof. John Horton Conway, the playful and legendary mathematician's wide range of contributions in science which includes research areas―Game of Life in cellular automata, theory of finite groups, knot theory, number theory, combinatorial game theory, and coding theory.  It contains transcripts where some eminent scientists have shared their first-hand experience of interacting with Conway, as well as some invited research articles from the experts focusing on Game of Life, cellular automata, and the diverse research directions that started with Conway's Game of Life. The book paints a portrait of Conway's research life and philosophical direction in mathematics and is of interest to whoever wants to explore his contribution to the history and philosophy of mathematics and computer science. It is designed as a small tribute to Prof. Conway whom we lost on April 11, 2020.