Rune Scale is set in a world ruled by dragons. Humans survive by their wits and through the use of alchemy, a mysterious magic possessively controlled by the secretive Alchemists Guild. Andrew Condign is an ordinary man with dreams of a better world, where humans can live without the constant fear of dragon attacks. In pursuit of this goal, Andrew finds himself in a race against time as he scrounges for scraps of knowledge and sets out on the most dangerous quest imaginable.